ISSN No.
2395-3306
(Online)
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 Volume  2 / Issue 1 / September 2015   (pp 1-52)
2D-QSAR Studies of Novel Quinazoline Derivatives for Their Potent Antimalarial Activity Abha Shrivastava1*, Ashish Shrivastava2
Int. J. Chem. Pharm. Rev. Res., 2015, 2(1), pp 1-10  •  Abstract  •  Fulltext    •   Citations: 0    •   Article Views: 0
 In the present study, quantitative structure activity relationship studies were performed on a series of novel quinazoline derivatives to find out the structural requirements of DHFRase inhibitors using V-Life MDS 3.5 software. Using an optimum combination of various molecular descriptors (constitutional, stearic, topological, electronic and hydrophobic), partial least square analysis was performed to derive various QSAR models. The developed models were cross-validated by the ‘leave one out’ technique. The best predictions were obtained from the model where 43 compounds were considered in the training set and 17 in the test set. The best QSAR model was selected having a correlation coefficient (r2) of 0.8531 and cross-validated correlation coefficient (q2) of 0.7361 and predicted r2 0.7002. This study indicates that steric descriptors play important role for the antimalarial activity. The results that are obtained from 2D QSAR studies may provide useful insights into the roles of various substitution patterns on the quinazoline skeleton and may also help to design more potent compounds.
Is Estimation of Residual Free Chlorine in Water by Drop Number Titration Method Reliable? Investigation of Statistical, Pragmatic, Psychological and Philosophical reasons Shashi Chawla1 , Renu Parashar2 and R.K.Parashar3*
Int. J. Chem. Pharm. Rev. Res., 2015, 2(1), pp 11-18  •  Abstract  •  Fulltext    •   Citations: 0    •   Article Views: 0
Poor sanitation, rise in population of pathogenic microorganisms and lack of access to hygienic water are considered the main causes of water borne diseases. Chlorination is the most common disinfection process as it is capable of maintaining residual disinfecting properties and is less costly.  Current methods used to monitor residual free chlorine require collection of a large volume of water, its transport to a testing laboratory, and its analysis using huge quantities of reagents which are found to be inconvenient and impractical in many parts of the world. To circumvent these limitations, we have developed and validated a method to measure residual free chlorine in water. The environmentally benign method involved the use of plastic Pasteur pipettes for delivery of desired number of drops. The data of estimated chlorine using the developed method from the 25 students were collected and statistical interpretation was done. The pragmatic, psychological and philosophical reasons were also explored for this method. The obtained results had good intermediate precision and accuracy. The main advantages of drop number titration method are less time required for analysis, energy savings, a drastic reduction of reagent consumption, and less waste generation. 
Crystal Structure, Conformation and Photo Chemistry of N-methyl-N-(2-methyl-1-phenylprop-1-enyl)benzamide. Sujit Kumar Dehury*
Int. J. Chem. Pharm. Rev. Res., 2015, 2(1), pp 19-24  •  Abstract  •  Fulltext    •   Citations: 0    •   Article Views: 0
 N-methyl-N-(2-methyl-1-phenylprop-1-enyl)benzamide (I) has empirical formula C18H19NO, crystallizes in the monoclinic space group, P 21/n, with unit cell parameters  a = 8.64930(10) Å, b = 15.4392(2) Å, c = 11.1670(2) Å, a= 90°, b= 99.4630(10)°, g = 90°, Z = 4. Interestingly, the compound ( I ) undergoes photocyclization upon irradiation of light to give isomerized product lactam A below 3100 Å. The photoreactant seems to undergo electrocyclization in the excited state to give a zwitterionic intermediate that rearranges to lactam A by a [1,5]-H shift. The quantum yield of the reaction was found to be 0.007. From 1H NMR spectroscopy, it is found that the title copound (I) exists in two conformations, i.e., Syn- and Anti- form. The ratios of the two conformers are found to be almost 10:1. The low value of the quantum yield can be explained on the basis of the conformational study. It may be possible that the minor conformer is only undergoing photochemical electrocyclization in the excited state which leads to a low value of the quantum yield 0.007.

Evaluation of Anti-oxidant Activity of Polyphenol in the Rhizome of Curcuma amada Alpa Mishra,1Reena Lawrence,1Kapil Lawrence, 2Ritika Singh*, 3Shailendra Kumar Amogh and 4ArchanaPandey
Int. J. Chem. Pharm. Rev. Res., 2015, 2(1), pp 25-29  •  Abstract  •  Fulltext    •   Citations: 0    •   Article Views: 0
The methanolic extracts of Curcuma amada were analyzed by HPLC, anti-oxidant activity and nitric oxide scavenging method. Seven components of Curcuma amada were identified and the major components were Gallic acid (2.499), P-HydroxyCinnamic acid (0.713),O-HydroxyCinnamic acid (1.445), Bisdemathoxycurcumin (3.458), Caffeic acid (15.717), ferulic acid (1.794) and curcumin (59.382). The methanolic extract concentration of DPPH free radical with an efficiency near to that of standard Gallic acid. The IC50 value was 0.24mg/mL for methanolic extract. In case of nitric oxide scavenging assay the antioxidant activity of methanolic extract was not closed to Gallic acid and BHT. IC50 value was 0.90mg/ml for essential oil. The phytochemical tests were total phenol, total tannin, and total flavonoid. In case of total phenol methanolic extract was very close to standard Gallic acid and the value is 0.25mg/ml GAE/mg. Total tannin of methanolic extract was close to standard tannic acid and value is 0.6 mg/mL GAE/mg and the total flavonoid of methanolic extract was close to standard qurecetine and the value is 0.4mg/mL GAE /mg. 
Development and Validation of Spectrophotometric Dual Wavelength Method for simultaneous Estimation of Alfuzosin Hydrochloride and Finasteride in combined dosage form Pinal Patel1*, Dhara Patel1, Sharav Desai2
Int. J. Chem. Pharm. Rev. Res., 2015, 2(1), pp 30-36  •  Abstract  •  Fulltext    •   Citations: 0    •   Article Views: 0
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical dual wavelength spectrophotometric method for the simultaneous determination of alfuzosin hydrochloride and finasteride in combined tablet dosage form.Dual wavelength method is “the absorbance difference between two points on the overlain spectra is directly proportional to the concentration of the component of interest”. 229.0 nm and 261.0 nm were selected for quantitation of both the drugs by proposed dual wavelength spectrophotometric method. The quantitative determination of ALFU is carried out by measuring the absorbance difference value at between 229.0 nm and 261.0 nm where ALFU have same absorbance at both the wavelengths. The difference between 229.0 nm and 261.0 nm is directly proportional to concentration of ALFU in the mixture. The quantitative determination of FINA is carried out by measuring the absorbance at 229.0 nm. The linearity was obtained in the concentration range of 2-12 μg/mL for both alfuzosin hydrochloride and finasteride. The mean % recovery was 100.09%and 100.35% for alfuzosin hydrochloride and finasteride, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of alfuzosin hydrochloride and finasteride in tablet dosage form. 
Heterocycles Antagonists: Synthesis and Anticancer screening against 60- cell lines D. Bhatta1* and J.M. Pattanaik2
Int. J. Chem. Pharm. Rev. Res., 2015, 2(1), pp 37-45  •  Abstract  •  Fulltext    •   Citations: 0    •   Article Views: 0
 New heterocycles, thiazole and quinazole derivatives are synthesized by adopting modified method and characterized by chemical analysis as well as by IR and 1H NMR. The compounds are screened for their anti-cancer activity at five different concentrations in a battery of about 60-cell lines of 8-types of human cancer at NCI, Bethesda, USA.
A Review on Manufacture of Bio-diesel from Trans-esterification process Sachin Gupta1, Amit Kumar Gupta2*
Int. J. Chem. Pharm. Rev. Res., 2015, 2(1), pp 46-52  •  Abstract  •  Fulltext    •   Citations: 0    •   Article Views: 0
 Biodiesel is an alternative fuel similar to conventional or ‘fossil’ diesel. Biodiesel can be produced from straight vegetable oil, animal oil/fats, tallow and waste cooking oil. The process used to convert these oils to Biodiesel is called trans-esterification. The largest possible source of suitable oil comes from oil crops, such as rapeseed, palm or soybean. In the UK rapeseed represents the greatest potential for biodiesel production. Most biodiesel produced at present is produced from waste vegetable oil sourced from restaurants, chip shops, industrial food producers, such as Birdseye, etc. Though oil straight from the agricultural industry represents the greatest potential source, it is not being produced commercially simply because the raw oil is too expensive. After the cost of converting it to biodiesel has been added on it is simply too expensive to compete with fossil diesel. Waste vegetable oil can often be sourced for free or sourced already treated for a small price. The result is Biodiesel produced from waste vegetable oil can compete with fossil diesel.
Editor

Prof. Upendra N. Dash (Ph.D, D.Sc)
Formerly Professor & Head
Utkal University, Bhubaneswar, India

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Dr. Sujit Kumar Dehury, Ph.D

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